CLEC5A is critical for dengue-virus-induced lethal disease

Szu-Ting Chen, Yi-Ling Lin, Ming-Ting Huang, Ming-Fang Wu, Shih-Chin Cheng, Huan-Yao Lei, Chien-Kuo Lee, Tzyy-Wen Chiou, Chi-Huey Wong and Shie-Liang Hsieh ()
Additional contact information
Szu-Ting Chen: National Yang-Ming University
Yi-Ling Lin: Institute of Biomedical Sciences, and,
Ming-Ting Huang: National Yang-Ming University
Ming-Fang Wu: National Yang-Ming University
Shih-Chin Cheng: National Yang-Ming University
Huan-Yao Lei: National Cheng Kung University
Chien-Kuo Lee: Institute of Immunology, National Taiwan University
Tzyy-Wen Chiou: National Dong Hwa University
Chi-Huey Wong: Genomics Research Center, Academia Sinica, Taipei 115, Taiwan
Shie-Liang Hsieh: National Yang-Ming University

Nature, 2008, vol. 453, issue 7195, 672-676

Abstract: Dengue virus: Reading the signals Dengue haemorrhagic fever is transmitted by the bite of a mosquito infected with dengue virus. It infects more that 50 million people a year and causes some 20,000 deaths, but at present there are no vaccines or therapies specific for the virus. The identification of the host proteins targeted by the virus and the signalling pathways responsible for controlling inflammation and antiviral immunity are essential for the development of therapeutic strategies. Szu-Ting Chen et al. have made a step towards that goal with the discovery that dengue virus interacts with the C-type lectin CLEC5A. The interaction promotes the production of pro-inflammatory cytokines and contributes to lethal disease in a mouse model.

Date: 2008
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DOI: 10.1038/nature07013

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