NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

Jordi Rius, Monica Guma, Christian Schachtrup, Katerina Akassoglou, Annelies S. Zinkernagel, Victor Nizet, Randall S. Johnson, Gabriel G. Haddad and Michael Karin ()
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Jordi Rius: Laboratory of Gene Regulation and Signal Transduction,
Monica Guma: Laboratory of Gene Regulation and Signal Transduction,
Christian Schachtrup: Department of Pharmacology,
Katerina Akassoglou: Department of Pharmacology,
Annelies S. Zinkernagel: School of Medicine
Victor Nizet: School of Medicine
Randall S. Johnson: Molecular Biology Section, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0723, USA
Gabriel G. Haddad: School of Medicine
Michael Karin: Laboratory of Gene Regulation and Signal Transduction,

Nature, 2008, vol. 453, issue 7196, 807-811

Abstract: Hypoxia and innate immunity: An old alliance Several lines of evidence have hinted at a possible connection between two evolutionarily ancient cellular defence mechanisms — innate immunity and the hypoxic response. Now that link has been clearly demonstrated with the discovery that a single protein is essential to both responses. The cellular response to hypoxia is triggered by low oxygen levels and controlled by hypoxia-inducible factor-1α (HIF-1α). The new work shows that HIF-1α transcription is regulated by the transcription factor NF-κB — more usually encountered as the master regulator of the innate immune response.

Date: 2008
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DOI: 10.1038/nature06905

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