An endogenous small interfering RNA pathway in Drosophila

Benjamin Czech, Colin D. Malone, Rui Zhou, Alexander Stark, Catherine Schlingeheyde, Monica Dus, Norbert Perrimon, Manolis Kellis, James A. Wohlschlegel, Ravi Sachidanandam, Gregory J. Hannon () and Julius Brennecke ()
Additional contact information
Benjamin Czech: Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
Colin D. Malone: Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
Rui Zhou: Harvard Medical School, Howard Hughes Medical Institute, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Alexander Stark: Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA
Catherine Schlingeheyde: Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
Monica Dus: Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
Norbert Perrimon: Harvard Medical School, Howard Hughes Medical Institute, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Manolis Kellis: Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA
James A. Wohlschlegel: David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
Ravi Sachidanandam: Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
Gregory J. Hannon: Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
Julius Brennecke: Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA

Nature, 2008, vol. 453, issue 7196, 798-802

Abstract: Endo-siRNAs in Drosophila In this work, Czech et al. identify a new class of small RNAs in Drosophila: endogenous short interfering RNAs (endo-siRNAs). These RNAs are present in both somatic and gonadal cells. Their processing is different than that of miRNAs or piRNAs; it requires Dcr2 and, unusually, Loqs, the Dcr1 partner, rather than R2D2, the usual partner of Dcr2. The processed endo-siRNAs are the first small RNAs found to associate preferentially with the Argonaute protein AGO2, and this complex targets genes that encode proteins as well as mobile elements.

Date: 2008
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DOI: 10.1038/nature07007

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