The Drosophila hairpin RNA pathway generates endogenous short interfering RNAs

Katsutomo Okamura, Wei-Jen Chung, J. Graham Ruby, Huili Guo, David P. Bartel and Eric C. Lai ()
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Katsutomo Okamura: Sloan-Kettering Institute, 521 Rockefeller Research Laboratories, 1275 York Avenue, Box 252, New York, New York 10065, USA
Wei-Jen Chung: Sloan-Kettering Institute, 521 Rockefeller Research Laboratories, 1275 York Avenue, Box 252, New York, New York 10065, USA
J. Graham Ruby: Massachusetts Institute of Technology, and Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Huili Guo: Massachusetts Institute of Technology, and Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
David P. Bartel: Massachusetts Institute of Technology, and Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Eric C. Lai: Sloan-Kettering Institute, 521 Rockefeller Research Laboratories, 1275 York Avenue, Box 252, New York, New York 10065, USA

Nature, 2008, vol. 453, issue 7196, 803-806

Abstract: Endo-siRNAs in Drosophila Short interfering RNAs (siRNAs) target cleavage of mRNAs with complementary sequences. In this work, Okamura et al. show that the Drosophila genome encodes endogenous siRNAs. Derived from long RNA hairpin genes, these siRNAs downregulate protein expression. Their processing pathway from the hairpin into the mature 21-nucleodite long siRNA involves factors of two pathways thought to be distinct.

Date: 2008
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DOI: 10.1038/nature07015

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