Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling

Jennifer S. Ziegenfuss, Romi Biswas, Michelle A. Avery, Kyoungja Hong, Amy E. Sheehan, Yee-Guide Yeung, E. Richard Stanley () and Marc R. Freeman ()
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Jennifer S. Ziegenfuss: University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605-2324, USA
Romi Biswas: Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
Michelle A. Avery: University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605-2324, USA
Kyoungja Hong: Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
Amy E. Sheehan: University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605-2324, USA
Yee-Guide Yeung: Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
E. Richard Stanley: Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
Marc R. Freeman: University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605-2324, USA

Nature, 2008, vol. 453, issue 7197, 935-939

Abstract: Targeting apoptotic cells for clearance Rapid clearance of apoptotic cells by phagocytosis is essential to prevent inflammation. This paper shows that glial cell phagocytosis in Drosophila requires the interaction of the engulfment receptor Draper with the non-receptor tyrosine kinase Shark through ITAM-like motifs. The Src family kinase Src42a is shown to phosphorylate Draper and thought to promote Shark binding.

Date: 2008
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DOI: 10.1038/nature06901

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