Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

Lars Guelen, Ludo Pagie, Emilie Brasset, Wouter Meuleman, Marius B. Faza, Wendy Talhout, Bert H. Eussen, Annelies de Klein, Lodewyk Wessels, Wouter de Laat and Bas van Steensel ()
Additional contact information
Lars Guelen: Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
Ludo Pagie: Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
Emilie Brasset: Department of Cell Biology and Genetics and,
Wouter Meuleman: Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
Marius B. Faza: Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
Wendy Talhout: Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
Bert H. Eussen: Erasmus Medical Centre, PO Box 2040, 3000 CA Rotterdam, The Netherlands
Annelies de Klein: Erasmus Medical Centre, PO Box 2040, 3000 CA Rotterdam, The Netherlands
Lodewyk Wessels: Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
Wouter de Laat: Department of Cell Biology and Genetics and,
Bas van Steensel: Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands

Nature, 2008, vol. 453, issue 7197, 948-951

Abstract: Chromosomal organization: Nuclear lamina interactions The architecture of human chromosomes within the nucleus is still a mystery. The nuclear lamina is thought to anchor specific DNA elements to help organize the genome within the nucleus. Van Steensel and colleagues report a high-resolution map of the sites of the human genome that contact the nuclear lamina. The map shows that interactions with the lamina occur via large yet sharply demarcated genomic domains. This domain structure is linked to the epigenetic and transcriptional profile of the genome. Many domain borders are marked by specific sequence elements, indicating that the higher-order folding of chromosomes is in part encoded in the genome itself.

Date: 2008
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DOI: 10.1038/nature06947

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