Global control of cell-cycle transcription by coupled CDK and network oscillators

David A. Orlando, Charles Y. Lin, Allister Bernard, Jean Y. Wang, Joshua E. S. Socolar, Edwin S. Iversen, Alexander J. Hartemink and Steven B. Haase ()
Additional contact information
David A. Orlando: Department of Biology,
Charles Y. Lin: Department of Biology,
Allister Bernard: Department of Computer Science,
Jean Y. Wang: Department of Biology,
Joshua E. S. Socolar: and
Edwin S. Iversen: Duke University, Durham, North Carolina 27708, USA
Alexander J. Hartemink: Department of Computer Science,
Steven B. Haase: Department of Biology,

Nature, 2008, vol. 453, issue 7197, 944-947

Abstract: The cell cycle: More regulators to look for During the cell cycle, many genes are transcribed in a periodic manner. A new study in Saccharomyces cerevisiae shows that a significant proportion of these genes continue to cycle in the absence of the major cell cycle regulatory cyclin/CDK complexes that control the G1-S transition. This suggests the existence of additional period regulators responsible for the periodic transcription of genes during the cell cycle.

Date: 2008
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DOI: 10.1038/nature06955

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