A phosphatase cascade by which rewarding stimuli control nucleosomal response

Alexandre Stipanovich, Emmanuel Valjent, Miriam Matamales, Akinori Nishi, Jung-Hyuck Ahn, Matthieu Maroteaux, Jesus Bertran-Gonzalez, Karen Brami-Cherrier, Hervé Enslen, Anne-Gaëlle Corbillé, Odile Filhol, Angus C. Nairn, Paul Greengard, Denis Hervé and Jean-Antoine Girault ()
Additional contact information
Alexandre Stipanovich: Inserm, UMR-S 839, 75005 Paris, France
Emmanuel Valjent: Inserm, UMR-S 839, 75005 Paris, France
Miriam Matamales: Inserm, UMR-S 839, 75005 Paris, France
Akinori Nishi: Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan
Jung-Hyuck Ahn: Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA
Matthieu Maroteaux: Inserm, UMR-S 839, 75005 Paris, France
Jesus Bertran-Gonzalez: Inserm, UMR-S 839, 75005 Paris, France
Karen Brami-Cherrier: Inserm, UMR-S 839, 75005 Paris, France
Hervé Enslen: Inserm, UMR-S 839, 75005 Paris, France
Anne-Gaëlle Corbillé: Inserm, UMR-S 839, 75005 Paris, France
Odile Filhol: Inserm, U873, CEA, 38054 Grenoble, France
Angus C. Nairn: Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA
Paul Greengard: Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA
Denis Hervé: Inserm, UMR-S 839, 75005 Paris, France
Jean-Antoine Girault: Inserm, UMR-S 839, 75005 Paris, France

Nature, 2008, vol. 453, issue 7197, 879-884

Abstract: Appetite and drug addiction Disruptions in dopamine signalling have been implicated in psychiatric disorders, such as schizophrenia and drug addiction. The phosphoprotein DARPP-32 is a prominent mediator of dopamine signalling in the striatum, a part of the brain where dopaminergic activation has been linked to reward and learning. Now a novel signal transduction cascade involving nuclear accumulation of DARPP-32 has been discovered, induced by both drugs of abuse and natural stimuli such as food. Disruption of this cascade alters the behavioural effects of the drugs and decreases motivation for food, suggesting a role for this mechanism in the in vivo actions of dopamine signalling.

Date: 2008
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature06994 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:453:y:2008:i:7197:d:10.1038_nature06994

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature06994

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().