Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate

Ferdia A. Gallagher, Mikko I. Kettunen, Sam E. Day, Hu De-En, Jan Henrik Ardenkjær-Larsen, René in ‘t Zandt, Pernille R. Jensen, Magnus Karlsson, Klaes Golman, Mathilde H. Lerche and Kevin M. Brindle ()
Additional contact information
Ferdia A. Gallagher: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
Mikko I. Kettunen: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
Sam E. Day: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
Hu De-En: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
Jan Henrik Ardenkjær-Larsen: GE Healthcare, The Grove Centre GC/18, White Lion Road, Amersham HP7 9LL, UK
René in ‘t Zandt: Imagnia AB, Box 8225, SE-200 41 Malmö, Sweden
Pernille R. Jensen: Imagnia AB, Box 8225, SE-200 41 Malmö, Sweden
Magnus Karlsson: Imagnia AB, Box 8225, SE-200 41 Malmö, Sweden
Klaes Golman: Imagnia AB, Box 8225, SE-200 41 Malmö, Sweden
Mathilde H. Lerche: Imagnia AB, Box 8225, SE-200 41 Malmö, Sweden
Kevin M. Brindle: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK

Nature, 2008, vol. 453, issue 7197, 940-943

Abstract: Translational research: MRI litmus test for tumours A low tissue pH is often associated with disease — for example cancer, ischaemia and inflammation — so a technique that could image tissue pH would have considerable potential for disease diagnosis and for monitoring response to treatment. A new, non-invasive method of pH imaging has now been devised, and demonstrated by monitoring the extracellular pH in living mice. It combines magnetic resonance imaging (MRI) and the intravenous injection of carbon-13-labelled bicarbonate — made extremely sensitive to detection by the use of dynamic nuclear polarization. Bicarbonate is a natural buffer in mammalian tissues, resisting pH change via interconversion with carbon dioxide in the reaction catalysed by carbonic anhydrase. The ratio of labelled bicarbonate to carbon dioxide can be used to calculate pH from the Henderson-Hasselbalch equation.

Date: 2008
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DOI: 10.1038/nature07017

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