Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient

Brian G. Fuller, Michael A. Lampson (), Emily A. Foley, Sara Rosasco-Nitcher, Kim V. Le, Page Tobelmann, David L. Brautigan, P. Todd Stukenberg () and Tarun M. Kapoor
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Brian G. Fuller: University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
Michael A. Lampson: University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Emily A. Foley: Laboratory of Chemistry and Cell Biology, The Rockefeller University, New York, New York 10021, USA
Sara Rosasco-Nitcher: University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
Kim V. Le: University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Page Tobelmann: University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
David L. Brautigan: Center for Cell Signaling, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
P. Todd Stukenberg: University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
Tarun M. Kapoor: Laboratory of Chemistry and Cell Biology, The Rockefeller University, New York, New York 10021, USA

Nature, 2008, vol. 453, issue 7198, 1132-1136

Abstract: Mitotic regulation: A phosphorylation gradient in anaphase Aurora B, a kinase important in mitosis, is now shown to generate a spatial gradient of phosphorylated substrates in anaphase with the highest concentration at the spindle midzone. Generation of this gradient involves a microtubule-dependent mechanism of aurora B activation. The gradient is proposed to provide important spatial information during mitosis.

Date: 2008
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DOI: 10.1038/nature06923

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