Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

Stephanie C. Eisenbarth, Oscar R. Colegio, William O’Connor, Fayyaz S. Sutterwala and Richard A. Flavell ()
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Stephanie C. Eisenbarth: Department of Immunobiology,
Oscar R. Colegio: Department of Immunobiology,
William O’Connor: Department of Immunobiology,
Fayyaz S. Sutterwala: Department of Immunobiology,
Richard A. Flavell: Department of Immunobiology,

Nature, 2008, vol. 453, issue 7198, 1122-1126

Abstract: Vaccination: What makes alum adjuvants tick Vaccines are frequently administered together with an adjuvant, a compound that boosts the immune response to the vaccine's active ingredient. One of the most popular adjuvants is aluminium hydroxide, or alum, which has been used for 80 years or so, because it works. How it works was not known — until now. Aluminium salts are shown to activate the Nalp3 inflammasome, an intracellular innate immune response system active in macrophages. Understanding how this widely used adjuvant acts could help in the design of more powerful, more specific adjuvants working in the same way.

Date: 2008
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DOI: 10.1038/nature06939

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