Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia

Keizo Kanasaki, Kristin Palmsten, Hikaru Sugimoto, Shakil Ahmad, Yuki Hamano, Liang Xie, Samuel Parry, Hellmut G. Augustin, Vincent H. Gattone, Judah Folkman, Jerome F. Strauss and Raghu Kalluri ()
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Keizo Kanasaki: Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Kristin Palmsten: Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Hikaru Sugimoto: Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Shakil Ahmad: The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Yuki Hamano: Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Liang Xie: Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Samuel Parry: University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6142, USA
Hellmut G. Augustin: Medical Faculty Mannheim, University of Heidelberg, and German Cancer Research Center Heidelberg
Vincent H. Gattone: Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Judah Folkman: Program in Vascular Biology, The Children’s Hospital Boston, Boston, Massachusetts 02215, USA
Jerome F. Strauss: School of Medicine, Virginia Commonwealth University, Richmond, Virginia 23298, USA
Raghu Kalluri: Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA

Nature, 2008, vol. 453, issue 7198, 1117-1121

Abstract: Pre-ecalmpsia: Prevention by 2-methoxyoestradiol Pre-eclampsia can be a serious complication during pregnancy. Kanasaki et al. now show that mice lacking the enzyme catechol-O-methyltransferase (COMT) develop a pre-eclampsia-like syndrome which can be ameliorated by 2-methoxyoestradiol (2-ME), which is produced by COMT. Although this novel mouse model doesn't completely recapitulate pre-eclampsia seen in women, the authors find that the levels of COMT and 2-ME are diminished in women with pre-eclampsia, suggesting that 2-ME might therefore be of therapeutic value.

Date: 2008
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DOI: 10.1038/nature06951

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