Induction and effector functions of TH17 cells

Estelle Bettelli, Thomas Korn, Mohamed Oukka and Vijay K. Kuchroo ()
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Estelle Bettelli: Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Thomas Korn: Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Mohamed Oukka: Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Vijay K. Kuchroo: Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA

Nature, 2008, vol. 453, issue 7198, 1051-1057

Abstract: T helper 17 cells: Induction and effector functions The recently discovered TH17 cells, the third subset of effector T helper cells, are the subject of intensive research. They produce the cytokine interleukin-17, coordinate defence against specific pathogens and mediate tissue inflammation. Bettelli et al. review this fast-moving field, focusing on the emergence of the balance between pro-inflammatory TH17 cells and inhibitory Treg cells as key factor in many inflammatory and autoimmune diseases.

Date: 2008
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DOI: 10.1038/nature07036

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