Translation factors promote the formation of two states of the closed-loop mRNP

Nadia Amrani, Shubhendu Ghosh, David A. Mangus and Allan Jacobson ()
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Nadia Amrani: University of Massachusetts Medical School, Worcester, Massachusetts 01655-0122, USA
Shubhendu Ghosh: University of Massachusetts Medical School, Worcester, Massachusetts 01655-0122, USA
David A. Mangus: University of Massachusetts Medical School, Worcester, Massachusetts 01655-0122, USA
Allan Jacobson: University of Massachusetts Medical School, Worcester, Massachusetts 01655-0122, USA

Nature, 2008, vol. 453, issue 7199, 1276-1280

Abstract: Closed-loop mRNP: The role of translation factors The 5′ and 3′ ends of eukaryotic mRNAs are brought together to form a closed loop. This involves the cap structure at the 5′ end of the mRNA, and the poly(A) tail that comprises the 3′ end. This loop structure helps stabilize the mRNA and facilitates translation. In this work, Amrani et al. find that there are two distinct closed loops formed in yeast, which differ in the form of the ribosome bound. The form containing the full ribosome is also surprisingly associated with termination factors, even though termination is not required for loop formation.

Date: 2008
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DOI: 10.1038/nature06974

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