Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution

Brian T. Wilhelm, Samuel Marguerat, Stephen Watt, Falk Schubert, Valerie Wood, Ian Goodhead, Christopher J. Penkett, Jane Rogers and Jürg Bähler ()
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Brian T. Wilhelm: Cancer Research UK Fission Yeast Functional Genomics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
Samuel Marguerat: Cancer Research UK Fission Yeast Functional Genomics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
Stephen Watt: Cancer Research UK Fission Yeast Functional Genomics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
Falk Schubert: Cancer Research UK Fission Yeast Functional Genomics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
Valerie Wood: Cancer Research UK Fission Yeast Functional Genomics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
Ian Goodhead: Cancer Research UK Fission Yeast Functional Genomics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
Christopher J. Penkett: Cancer Research UK Fission Yeast Functional Genomics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
Jane Rogers: Cancer Research UK Fission Yeast Functional Genomics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
Jürg Bähler: Cancer Research UK Fission Yeast Functional Genomics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK

Nature, 2008, vol. 453, issue 7199, 1239-1243

Abstract: Genome expression: A hive of activity Until recently, it was thought that much of a genome sequence is silent for much of the time. Now a study in the fission yeast Schizosaccharomyces pombe, using recently developed DNA sequencing technologies, shows that almost all of the yeast genome is genetically active. More than 90% of the genome is transcribed into RNA, including more than 450 newly discovered transcripts, many of them non-coding, with regulatory or other unknown roles.

Date: 2008
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DOI: 10.1038/nature07002

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