A myocardial lineage derives from Tbx18 epicardial cells

Chen-Leng Cai, Jody C. Martin, Yunfu Sun, Li Cui, Lianchun Wang, Kunfu Ouyang, Lei Yang, Lei Bu, Xingqun Liang, Xiaoxue Zhang, William B. Stallcup, Christopher P. Denton, Andrew McCulloch, Ju Chen and Sylvia M. Evans ()
Additional contact information
Chen-Leng Cai: Skaggs School of Pharmacy,
Jody C. Martin: Department of Bioengineering,
Yunfu Sun: Skaggs School of Pharmacy,
Li Cui: Skaggs School of Pharmacy,
Lianchun Wang: Complex Carbohydrate Research Centre, University of Georgia, Athens, Georgia 30602, USA
Kunfu Ouyang: University of California, San Diego, La Jolla, California 92093, USA
Lei Yang: Skaggs School of Pharmacy,
Lei Bu: Skaggs School of Pharmacy,
Xingqun Liang: University of California, San Diego, La Jolla, California 92093, USA
Xiaoxue Zhang: Skaggs School of Pharmacy,
William B. Stallcup: Developmental Neurobiology Programme, The Burnham Institute, La Jolla, California 92037, USA
Christopher P. Denton: Centre for Rheumatology, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
Andrew McCulloch: Department of Bioengineering,
Ju Chen: University of California, San Diego, La Jolla, California 92093, USA
Sylvia M. Evans: Skaggs School of Pharmacy,

Nature, 2008, vol. 454, issue 7200, 104-108

Abstract: Cardiac repair: New myocyte lineages Knowledge of the nature of cardiac progenitor cells is important for an understanding of the development of heart diseases, and as a potential route to regenerative therapy using stem cells. Two groups now report previously unknown cardiac myocyte lineages isolated from the proepicardium of the mouse. Cai et al. identify a population of progenitor cells that express the transcription factor Tbx18, and Zhou et al. identify cells marked by the transcription factor Wt1. Both types of progenitor are pluripotent, capable of producing several different classes of heart cell, making them promising candidates for use in cardiac repair.

Date: 2008
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DOI: 10.1038/nature06969

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