Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription

Xiangting Wang, Shigeki Arai, Xiaoyuan Song, Donna Reichart, Kun Du, Gabriel Pascual, Paul Tempst, Michael G. Rosenfeld (), Christopher K. Glass () and Riki Kurokawa ()
Additional contact information
Xiangting Wang: Howard Hughes Medical Institute,
Shigeki Arai: Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka-shi, Saitama-Ken, Mail code 350-1241, Japan
Xiaoyuan Song: Howard Hughes Medical Institute,
Donna Reichart: and
Kun Du: Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka-shi, Saitama-Ken, Mail code 350-1241, Japan
Gabriel Pascual: and
Paul Tempst: Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
Michael G. Rosenfeld: Howard Hughes Medical Institute,
Christopher K. Glass: and
Riki Kurokawa: Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka-shi, Saitama-Ken, Mail code 350-1241, Japan

Nature, 2008, vol. 454, issue 7200, 126-130

Abstract: Gene transcription: Inhibition by non-coding RNAs DNA damage induces expression of a non-coding RNA, which acts like a ligand to recruit a specific RNA-binding protein, TLS. This protein in turn represses transcription of the gene to which the non-coding RNA is tethered by inhibiting a histone acetyltransferase coactivator. These data suggest that non-coding RNAs induced in regulatory regions of transcription units recruit and modulate the activities of distinct classes of RNA binding co-regulators in response to specific signalling programs, providing an unexpected RNA-based strategy to integrate transcriptional programs.

Date: 2008
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DOI: 10.1038/nature06992

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