Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving

Kelly L. Conrad, Kuei Y. Tseng, Jamie L. Uejima, Jeremy M. Reimers, Li-Jun Heng, Yavin Shaham, Michela Marinelli and Marina E. Wolf ()
Additional contact information
Kelly L. Conrad: Department of Neuroscience and,
Kuei Y. Tseng: Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, Illinois 60064, USA
Jamie L. Uejima: Behavioral Neuroscience Branch, IRP/NIDA/NIH, 251 Bayview Boulevard, Baltimore, Maryland 21224, USA
Jeremy M. Reimers: Department of Neuroscience and,
Li-Jun Heng: Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, Illinois 60064, USA
Yavin Shaham: Behavioral Neuroscience Branch, IRP/NIDA/NIH, 251 Bayview Boulevard, Baltimore, Maryland 21224, USA
Michela Marinelli: Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, Illinois 60064, USA
Marina E. Wolf: Department of Neuroscience and,

Nature, 2008, vol. 454, issue 7200, 118-121

Abstract: The craving for cocaine Relapse to cocaine use after abstinence is often induced by drug-associated cues, but what mediates this reactivity of neurons to these cues is not fully understood. Cocaine-seeking depends on activation of glutamatergic AMPA receptors in the nucleus accumbens. Conrad et al. show that the number of AMPA receptors increases during abstinence in rats, and that the new receptors have a higher conductance. The additional receptors were critical for the increased reactivity of nucleus accumbens neurons to cocaine-related cues, suggesting a novel target for treating relapse.

Date: 2008
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DOI: 10.1038/nature06995

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