Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart

Bin Zhou, Qing Ma, Satish Rajagopal, Sean M. Wu, Ibrahim Domian, José Rivera-Feliciano, Dawei Jiang, Alexander von Gise, Sadakatsu Ikeda, Kenneth R. Chien and William T. Pu ()
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Bin Zhou: Children’s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
Qing Ma: Children’s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
Satish Rajagopal: Children’s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
Sean M. Wu: Harvard Stem Cell Institute, Harvard University and Cardiovascular Research Center, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, USA
Ibrahim Domian: Harvard Stem Cell Institute, Harvard University and Cardiovascular Research Center, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, USA
José Rivera-Feliciano: Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Dawei Jiang: Children’s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
Alexander von Gise: Children’s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
Sadakatsu Ikeda: Children’s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
Kenneth R. Chien: Harvard Stem Cell Institute, Harvard University and Cardiovascular Research Center, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, USA
William T. Pu: Children’s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA

Nature, 2008, vol. 454, issue 7200, 109-113

Abstract: Cardiac repair: New myocyte lineages Knowledge of the nature of cardiac progenitor cells is important for an understanding of the development of heart diseases, and as a potential route to regenerative therapy using stem cells. Two groups now report previously unknown cardiac myocyte lineages isolated from the proepicardium of the mouse. Cai et al. identify a population of progenitor cells that express the transcription factor Tbx18, and Zhou et al. identify cells marked by the transcription factor Wt1. Both types of progenitor are pluripotent, capable of producing several different classes of heart cell, making them promising candidates for use in cardiac repair.

Date: 2008
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DOI: 10.1038/nature07060

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