Imaging the biogenesis of individual HIV-1 virions in live cells

Nolwenn Jouvenet, Paul D. Bieniasz () and Sanford M. Simon ()
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Nolwenn Jouvenet: Aaron Diamond AIDS Research Center,
Paul D. Bieniasz: Aaron Diamond AIDS Research Center,
Sanford M. Simon: Laboratory of Cellular Biophysics, The Rockefeller University, New York, New York 10065, USA

Nature, 2008, vol. 454, issue 7201, 236-240

Abstract: HIV/AIDS: Movie of virus particle assembly For the first time, the assembly of a virus particle has been observed directly in live cells. Using techniques based on total internal reflection fluorescence microscopy, and live HeLa cells expressing fluorescent protein-tagged derivatives of Gag, the major structural component of HIV-1, individual HIV-1 virus particles were observed in real time. The resulting movies resolve a controversy over where in the cells HIV-1 assembly occurs — the virions appear individually at the plasma membrane and are assembled in about 5 or 6 minutes.

Date: 2008
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DOI: 10.1038/nature06998

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