Essential role for Nix in autophagic maturation of erythroid cells

Hector Sandoval, Perumal Thiagarajan, Swapan K. Dasgupta, Armin Schumacher, Josef T. Prchal, Min Chen () and Jin Wang ()
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Hector Sandoval: Departments of Immunology,
Perumal Thiagarajan: Pathology and,
Swapan K. Dasgupta: Pathology and,
Armin Schumacher: Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Josef T. Prchal: University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
Min Chen: Departments of Immunology,
Jin Wang: Departments of Immunology,

Nature, 2008, vol. 454, issue 7201, 232-235

Abstract: Erythroid cell maturation: Then need for Nix Erythroid cells undergo enucleation and the removal of organelles during terminal differentiation. This paper shows that a member of the Bcl-2 family, Nix/Bnip3L, helps eliminate organelles by by autophagy (or 'eating') of the mitochondria. Nix−/− mice developed anaemia with reduced mature erythrocytes and compensatory expansion of erythroid precursors. Erythrocytes in the peripheral blood of Nix−/− mice exhibited mitochondrial retention and reduced lifespan in vivo. This work may shed light on the mechanisms for various anaemic conditions associated with defective autophagy. It may also help to understand the molecular regulation of autophagy under normal and disease settings in other cell types.

Date: 2008
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DOI: 10.1038/nature07006

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