Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia

Aline Bozec, Latifa Bakiri, Astrid Hoebertz, Robert Eferl, Arndt F. Schilling, Vukoslav Komnenovic, Harald Scheuch, Matthias Priemel, Colin L. Stewart, Michael Amling and Erwin F. Wagner ()
Additional contact information
Aline Bozec: Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria
Latifa Bakiri: Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria
Astrid Hoebertz: Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria
Robert Eferl: Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria
Arndt F. Schilling: Center for Biomechanics and Skeletal Biology, Hand, and Reconstructive Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany
Vukoslav Komnenovic: Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria
Harald Scheuch: Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria
Matthias Priemel: Center for Biomechanics and Skeletal Biology, Hand, and Reconstructive Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany
Colin L. Stewart: Developmental and Regenerative Biology Laboratory, Institute of Medical Biology (I.M.B.), 8A Biomedical Grove, #06-06 Immunos, 138648 Singapore
Michael Amling: Center for Biomechanics and Skeletal Biology, Hand, and Reconstructive Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany
Erwin F. Wagner: Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria

Nature, 2008, vol. 454, issue 7201, 221-225

Abstract: Bone-destructive diseases: The role of osteoclast size Osteoclasts are cells that resorb bone. Too many of them, and osteoporosis — a common metabolic disorder of the skeleton — can result, as well as several other diseases. Although the protein c-Fos plays an essential part in the formation of osteoclasts, the specific role of related protein Fra-2 has been unclear. Here Fra-2 is shown to control osteoclast survival and size in newborn mice, in a process involving a novel biochemical pathway that includes the protein LIF as well as hypoxia. The Fra-2 exerts this effect from within the placenta, rather than the embryo itself. This suggests that placental-induced hypoxia during embryogenesis leads to giant osteoclast formation in young pups. This work provides the basis for developing new strategies aimed at manipulating osteoclast activity, improving disease diagnostics and understanding the pathogenesis of bone loss syndromes.

Date: 2008
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature07019 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:454:y:2008:i:7201:d:10.1038_nature07019

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature07019

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().