Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells

Morgan E. Carlson, Michael Hsu and Irina M. Conboy ()
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Morgan E. Carlson: University of California, Berkeley, California 94720, USA
Michael Hsu: University of California, Berkeley, California 94720, USA
Irina M. Conboy: University of California, Berkeley, California 94720, USA

Nature, 2008, vol. 454, issue 7203, 528-532

Abstract: Making muscle young again The reduced ability of ageing muscle tissue to regenerate and repair itself has been found to result from high levels of TGF-β in the muscle stem cells, or satellite cells. Comparison of the muscle regeneration capacity of 2-year-old mice (equivalent to 75- to 80-year-old humans), with that of 2-month-old mice (equivalent to a 20- to 25-year-old) shows that success versus failure in muscle repair is determined by a balance between the levels of TGF-β/pSmad3 signalling and the activation of the Notch pathway. The work raises the possibility of developing therapeutic interventions to restore a stem-cell microniche in old muscle.

Date: 2008
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DOI: 10.1038/nature07034

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