Saccharomyces cerevisiae ATM orthologue suppresses break-induced chromosome translocations

Kihoon Lee, Yu Zhang and Sang Eun Lee ()
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Kihoon Lee: University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA
Yu Zhang: University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA
Sang Eun Lee: University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA

Nature, 2008, vol. 454, issue 7203, 543-546

Abstract: Tel-tail signs of chromosome healing Chromosomal translocations are characteristic of some leukaemias and childhood sarcomas. They are thought to be initiated by DNA breaks that are repaired by non-homologous end joining, a process which links, or 'heals', any two broken ends, regardless of whether they arose from the same double-strand break. In this work, Lee et al. have devised a system to replicate this type of translocation event in yeast. Using this system they find that Tel1, the yeast homologue of the ATM kinase which is mutated in ataxia-telangiectasia, is a key factor in suppressing non-homologous end joining of interchromosomal DNA ends.

Date: 2008
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DOI: 10.1038/nature07054

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