Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation

Riina M. Luik, Bin Wang, Murali Prakriya, Minnie M. Wu and Richard S. Lewis ()
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Riina M. Luik: Stanford University School of Medicine, Stanford, California 94305, USA
Bin Wang: Stanford University School of Medicine, Stanford, California 94305, USA
Murali Prakriya: Stanford University School of Medicine, Stanford, California 94305, USA
Minnie M. Wu: Stanford University School of Medicine, Stanford, California 94305, USA
Richard S. Lewis: Stanford University School of Medicine, Stanford, California 94305, USA

Nature, 2008, vol. 454, issue 7203, 538-542

Abstract: Calcium in the endoplasmic reticulum STIM1 is the messenger that signals endoplasmic reticulum Ca2+ store depletion and subsequently activates the store-operated channel ORAI. However, its precise mechanism of action is unclear. Here, Luik et al. show that STIM oligomerzation, not the concentration of Ca2+ in the endoplasmic reticulum, is the key event that triggers ORAI activation.

Date: 2008
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DOI: 10.1038/nature07065

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