Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA

Takeshi Saito, David M. Owen, Fuguo Jiang, Joseph Marcotrigiano and Michael Gale ()
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Takeshi Saito: University of Washington School of Medicine, Seattle, Washington 98195-7650, USA
David M. Owen: University of Washington School of Medicine, Seattle, Washington 98195-7650, USA
Fuguo Jiang: Rutgers University, Piscataway, New Jersey 08854, USA
Joseph Marcotrigiano: Rutgers University, Piscataway, New Jersey 08854, USA
Michael Gale: University of Washington School of Medicine, Seattle, Washington 98195-7650, USA

Nature, 2008, vol. 454, issue 7203, 523-527

Abstract: Hepatitis C recognition Innate immunity is an important defence against infection by viruses, triggered by host recognition of 'PAMPS', or pathogen-associated molecular patterns. Saito et al. have now identified a conserved poly-uridine motif in the 3´ non-transcribed region of the hepatitis C virus genome as the relevant PAMP for detection by the RNA helicase RIG-I, a protein previously shown to have an essential function in double-stranded RNA-induced innate antiviral responses.

Date: 2008
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DOI: 10.1038/nature07106

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