The role of exercise and PGC1α in inflammation and chronic disease

Christoph Handschin and Bruce M. Spiegelman
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Christoph Handschin: Institute of Physiology and Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich
Bruce M. Spiegelman: Harvard Medical School

Nature, 2008, vol. 454, issue 7203, 463-469

Abstract: Abstract Inadequate physical activity is linked to many chronic diseases. But the mechanisms that tie muscle activity to health are unclear. The transcriptional coactivator PGC1α has recently been shown to regulate several exercise-associated aspects of muscle function. We propose that this protein controls muscle plasticity, suppresses a broad inflammatory response and mediates the beneficial effects of exercise.

Date: 2008
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DOI: 10.1038/nature07206

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