Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors

Jeong Beom Kim, Holm Zaehres, Guangming Wu, Luca Gentile, Kinarm Ko, Vittorio Sebastiano, Marcos J. Araúzo-Bravo, David Ruau, Dong Wook Han, Martin Zenke and Hans R. Schöler ()
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Jeong Beom Kim: Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, 48149 Münster, NRW, Germany
Holm Zaehres: Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, 48149 Münster, NRW, Germany
Guangming Wu: Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, 48149 Münster, NRW, Germany
Luca Gentile: Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, 48149 Münster, NRW, Germany
Kinarm Ko: Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, 48149 Münster, NRW, Germany
Vittorio Sebastiano: Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, 48149 Münster, NRW, Germany
Marcos J. Araúzo-Bravo: Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, 48149 Münster, NRW, Germany
David Ruau: Institute for Biomedical Engineering, RWTH Aachen University Medical School, Pauwelsstrasse 30, 52074 Aachen, NRW, Germany
Dong Wook Han: Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, 48149 Münster, NRW, Germany
Martin Zenke: Institute for Biomedical Engineering, RWTH Aachen University Medical School, Pauwelsstrasse 30, 52074 Aachen, NRW, Germany
Hans R. Schöler: Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, 48149 Münster, NRW, Germany

Nature, 2008, vol. 454, issue 7204, 646-650

Abstract: Stem cells: towards simpler, safer iPS cells The process of reprogramming somatic cells, the 'ordinary' cells that make up most body tissues, to become induced pluripotent stem cells (iPS cells) involves the expression of four transcription factors — Oct4, Sox2, c-Myc and Klf4. With a view to making the procedure simpler and potentially safer in clinical applications, efforts to reduce the number of transgenes required, and to eliminate the need for the oncogene c-Myc, are under way. Kim et al. now show that just two endogenous factors — Oct4 plus either Klf4 or c-Myc — are sufficient to generate iPS cells from adult mouse neural stem cells. This is possible because these neural cells express higher endogenous levels of Sox2 and c-Myc than embryonic stem cells, pointing to somatic cells with a suitable natural complement of transcription factors as a potentially useful starting point for iPS cell production.

Date: 2008
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DOI: 10.1038/nature07061

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