Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation

Tuomas Tammela, Georgia Zarkada, Elisabet Wallgard, Aino Murtomäki, Steven Suchting, Maria Wirzenius, Marika Waltari, Mats Hellström, Tibor Schomber, Reetta Peltonen, Catarina Freitas, Antonio Duarte, Helena Isoniemi, Pirjo Laakkonen, Gerhard Christofori, Seppo Ylä-Herttuala, Masabumi Shibuya, Bronislaw Pytowski, Anne Eichmann, Christer Betsholtz and Kari Alitalo ()
Additional contact information
Tuomas Tammela: Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and the Haartman Institute University of Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 Helsinki, Finland
Georgia Zarkada: Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and the Haartman Institute University of Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 Helsinki, Finland
Elisabet Wallgard: Karolinska Institutet
Aino Murtomäki: Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and the Haartman Institute University of Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 Helsinki, Finland
Steven Suchting: Institut National de la Santé et de la Recherche Médicale U833, Collège de France, 11 Place Marcelin Berthelot, 75005 Paris, France
Maria Wirzenius: Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and the Haartman Institute University of Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 Helsinki, Finland
Marika Waltari: Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and the Haartman Institute University of Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 Helsinki, Finland
Mats Hellström: Karolinska Institutet
Tibor Schomber: Center of Biomedicine, University of Basel, Mattenstrasse 28, CH-4058 Basel, Switzerland
Reetta Peltonen: Helsinki University Central Hospital, PO Box 263, 00029 Helsinki, Finland
Catarina Freitas: Institut National de la Santé et de la Recherche Médicale U833, Collège de France, 11 Place Marcelin Berthelot, 75005 Paris, France
Antonio Duarte: The Interdisciplinary Centre of Research in Animal Health (CIISA), Faculty of Veterinary Medicine, Technical University of Lisbon
Helena Isoniemi: Helsinki University Central Hospital, PO Box 263, 00029 Helsinki, Finland
Pirjo Laakkonen: Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and the Haartman Institute University of Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 Helsinki, Finland
Gerhard Christofori: Center of Biomedicine, University of Basel, Mattenstrasse 28, CH-4058 Basel, Switzerland
Seppo Ylä-Herttuala: University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
Masabumi Shibuya: Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8519, Japan
Bronislaw Pytowski: ImClone Systems, 180 Varick Street, New York 10014, USA
Anne Eichmann: Institut National de la Santé et de la Recherche Médicale U833, Collège de France, 11 Place Marcelin Berthelot, 75005 Paris, France
Christer Betsholtz: Karolinska Institutet
Kari Alitalo: Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and the Haartman Institute University of Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 Helsinki, Finland

Nature, 2008, vol. 454, issue 7204, 656-660

Abstract: Anti-angiogenesis: VEGFR-3 shows its paces The vascular endothelial growth factor (VEGF) receptor subtype VEGFR-3 is expressed only on lymphatic endothelium in adults. A new study, however, finds that VEGFR-3 is upregulated in the vasculature of tumours by Notch signalling. VEGFR-3 inhibition interferes with tumour angiogenesis and tumour growth, in particular in combination with inhibitors of VEGFR-2, suggesting that it represents a novel anti-angiogenic target for cancer therapy.

Date: 2008
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DOI: 10.1038/nature07083

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