The behaviour of Drosophila adult hindgut stem cells is controlled by Wnt and Hh signalling

Shigeo Takashima, Marianna Mkrtchyan, Amelia Younossi-Hartenstein, John R. Merriam and Volker Hartenstein ()
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Shigeo Takashima: Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, California 90095, USA
Marianna Mkrtchyan: Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, California 90095, USA
Amelia Younossi-Hartenstein: Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, California 90095, USA
John R. Merriam: Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, California 90095, USA
Volker Hartenstein: Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, California 90095, USA

Nature, 2008, vol. 454, issue 7204, 651-655

Abstract: Genetic control of stem cells Genetically tractable animals like Drosophila are ideal models for the study of the gene networks that control stem cell function. Takashima et al. now describe a novel system in Drosophila, the stem cells of the hindgut, that may be of value for the study of the specification and control of stem cells in general. As intestinal tract cells age, they are replaced by new ones produced by self-renewing intestinal stem cells (ISCs). In Drosophila the ISCs are confined to a narrow segment of the intestine, the hindgut proliferation zone (HPZ). Self renewal here is controlled by the Wingless (a Drosophila Wnt homologue) and Hedgehog signalling pathways in a manner that is remarkably similar to that seen in mammalian intestine.

Date: 2008
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DOI: 10.1038/nature07156

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