Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex

Yong Gong, Peng Cao, Hong-jun Yu and Tao Jiang ()
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Yong Gong: National Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China
Peng Cao: National Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China
Hong-jun Yu: National Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China
Tao Jiang: National Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China

Nature, 2008, vol. 454, issue 7205, 789-793

Abstract: Neurotrophins and the p75NTR receptor Neurotrophins (NTs) are key factors for the development and maintenance of the mammalian nervous system. The binding of neurotrophins to the p75NTR receptor induces either cell survival or apoptosis. p75NTR also plays a very important role in Alzheimer's disease, tumour development and metastasis. In spite of this knowledge, the fundamental mechanism of interaction between p75NTR and neurotrophins is not clear. Here Yong Gong et al. report the crystal structure of a 2:2 symmetrical complex of neurotrophin-3 (NT-3) and p75NTR. The structure reveals the detailed interaction mode between p75NTR and NT-3, and provides a basis to understand diverse p75NTR functions and facilitate the therapeutic utility of neurotrophins as clinical agents.

Date: 2008
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DOI: 10.1038/nature07089

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