cAMP signalling in mushroom bodies modulates temperature preference behaviour in Drosophila

Sung-Tae Hong, Sunhoe Bang, Seogang Hyun, Jongkyun Kang, Kyunghwa Jeong, Donggi Paik, Jongkyeong Chung and Jaeseob Kim ()
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Sung-Tae Hong: Korea Advanced Institute of Science & Technology, Guseong-Dong, Yusong-Gu, Daejeon, 305-701, Korea
Sunhoe Bang: Korea Advanced Institute of Science & Technology, Guseong-Dong, Yusong-Gu, Daejeon, 305-701, Korea
Seogang Hyun: Korea Advanced Institute of Science & Technology, Guseong-Dong, Yusong-Gu, Daejeon, 305-701, Korea
Jongkyun Kang: Korea Advanced Institute of Science & Technology, Guseong-Dong, Yusong-Gu, Daejeon, 305-701, Korea
Kyunghwa Jeong: Korea Advanced Institute of Science & Technology, Guseong-Dong, Yusong-Gu, Daejeon, 305-701, Korea
Donggi Paik: Korea Advanced Institute of Science & Technology, Guseong-Dong, Yusong-Gu, Daejeon, 305-701, Korea
Jongkyeong Chung: Korea Advanced Institute of Science & Technology, Guseong-Dong, Yusong-Gu, Daejeon, 305-701, Korea
Jaeseob Kim: Korea Advanced Institute of Science & Technology, Guseong-Dong, Yusong-Gu, Daejeon, 305-701, Korea

Nature, 2008, vol. 454, issue 7205, 771-775

Abstract: Body temperature Neurons in the mushroom body structures of the fruit fly's brain are essential to processes such as learning, memory and sleep regulation. A study by Sung-Tae Hong et al. shows that they also play a role in temperature preference behaviour. Some animals, like us, regulate body temperature internally by changing their metabolism. But for others, like Drosophila, body temperature is a result of heat exchange with their environment. Drosophila instinctively seek an environment to match a genetically preferred body temperature, a process analogous to the mammalian set point temperature. When cyclic AMP-dependent kinase activity in mushroom body neurons is artificially lowered, flies are unable to find their desired temperature; when it is increased, they favour high temperatures. This work suggests that temperature sensation may share some cellular mechanisms with learning and memory.

Date: 2008
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DOI: 10.1038/nature07090

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