Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis

Shidong Jia, Zhenning Liu, Sen Zhang, Pixu Liu, Lei Zhang, Sang Hyun Lee, Jing Zhang, Sabina Signoretti, Massimo Loda, Thomas M. Roberts () and Jean J. Zhao ()
Additional contact information
Shidong Jia: Department of Cancer Biology and,
Zhenning Liu: Department of Cancer Biology and,
Sen Zhang: Department of Cancer Biology and,
Pixu Liu: Department of Cancer Biology and,
Lei Zhang: Department of Cancer Biology and,
Sang Hyun Lee: Department of Cancer Biology and,
Jing Zhang: Department of Cancer Biology and,
Sabina Signoretti: Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
Massimo Loda: Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
Thomas M. Roberts: Department of Cancer Biology and,
Jean J. Zhao: Department of Cancer Biology and,

Nature, 2008, vol. 454, issue 7205, 776-779

Abstract: Insulin-induced changes in tumours The two most widely expressed isoforms of class 1 PI3 kinases are p110alpha and p110beta. Previously, the p110-alpha isoform has been implicated in growth factor and insulin signalling, as well as in tumorigenesis. Now the analysis of mutant mice reveals a major role for p110-beta in the regulation of insulin-dependent metabolic changes and in tumour formation. Interestingly, some of the effects are mediated by a kinase-independent function of p110-beta.

Date: 2008
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DOI: 10.1038/nature07091

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