A mechanism for asymmetric segregation of age during yeast budding

Zhanna Shcheprova, Sandro Baldi, Stephanie Buvelot Frei, Gaston Gonnet and Yves Barral ()
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Zhanna Shcheprova: Institute of Biochemistry, ETH Zurich, Schafmattstrasse 18, 8093 Zurich, Switzerland
Sandro Baldi: Institute of Biochemistry, ETH Zurich, Schafmattstrasse 18, 8093 Zurich, Switzerland
Stephanie Buvelot Frei: Institute of Biochemistry, ETH Zurich, Schafmattstrasse 18, 8093 Zurich, Switzerland
Gaston Gonnet: Institute of Computational Science, ETH Zurich, Universtätstrasse 6, 8092 Zürich, Switzerland
Yves Barral: Institute of Biochemistry, ETH Zurich, Schafmattstrasse 18, 8093 Zurich, Switzerland

Nature, 2008, vol. 454, issue 7205, 728-734

Abstract: Abstract Ageing and the mortality that ensues are sustainable for the species only if age is reset in newborns. In budding yeast, buds are made young whereas ageing factors, such as carbonylated proteins and DNA circles, remain confined to the ageing mother cell. The mechanisms of this confinement and their relevance are poorly understood. Here we show that a septin-dependent, lateral diffusion barrier forms in the nuclear envelope and limits the translocation of pre-existing nuclear pores into the bud. The retention of DNA circles within the mother cell depends on the presence of the diffusion barrier and on the anchorage of the circles to pores mediated by the nuclear basket. In accordance with the diffusion barrier ensuring the asymmetric segregation of nuclear age-determinants, the barrier mutant bud6Δ fails to properly reset age in buds. Our data involve septin-dependent diffusion barriers in the confinement of ageing factors to one daughter cell during asymmetric cell division.

Date: 2008
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DOI: 10.1038/nature07212

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