A discontinuous hammerhead ribozyme embedded in a mammalian messenger RNA

Monika Martick (), Lucas H. Horan, Harry F. Noller and William G. Scott
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Monika Martick: Center for Molecular Biology of RNA, University of California, Santa Cruz, California 95064, USA
Lucas H. Horan: Center for Molecular Biology of RNA, University of California, Santa Cruz, California 95064, USA
Harry F. Noller: Center for Molecular Biology of RNA, University of California, Santa Cruz, California 95064, USA
William G. Scott: Center for Molecular Biology of RNA, University of California, Santa Cruz, California 95064, USA

Nature, 2008, vol. 454, issue 7206, 899-902

Abstract: Hammerhead ribozyme and gene regulation An active ribozyme which can regulate gene expression was previously identified in bacteria, but whether there are similar regulatory ribozymes in eukaryotes was unknown. In this study, Martick et al. identify active ribozymes in the 3' UTRs of several rodent lectin genes. Unusually, these hammerhead ribozymes have a split structure, such that both halves must self-cleave and reassemble to give activity. Some data show that these ribozymes may potentially regulate gene expression, although further work will be necessary to confirm this function.

Date: 2008
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DOI: 10.1038/nature07117

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