Drosophila RNAi screen identifies host genes important for influenza virus replication

Linhui Hao, Akira Sakurai, Tokiko Watanabe, Ericka Sorensen, Chairul A. Nidom, Michael A. Newton, Paul Ahlquist () and Yoshihiro Kawaoka ()
Additional contact information
Linhui Hao: Institute for Molecular Virology,
Akira Sakurai: and
Tokiko Watanabe: and
Ericka Sorensen: Institute for Molecular Virology,
Chairul A. Nidom: Faculty of Veterinary Medicine, and,
Michael A. Newton: University of Wisconsin-Madison, Madison, Wisconsin 53706, USA
Paul Ahlquist: Institute for Molecular Virology,
Yoshihiro Kawaoka: and

Nature, 2008, vol. 454, issue 7206, 890-893

Abstract: Flu in a fruit fly: the search for new antivirals Although several alternative antivirals are available for the treatment of influenza virus infection, the risk that viruses resistant to these drugs will emerge means it is important to continue the search for new antiviral targets. Hao et al. have recruited a new ally to this cause: by modifying influenza virus so that it can infect the cells of the fruit fly Drosophila, they have been able to use a powerful genome-wide RNA interference (RNAi) screen to identify scores of host genes that the pathogen requires for successful infection. Several host proteins were found that have key functions in the replication of H5N1 and H1N1 influenza A viruses — but not other viruses — in human cells. The same strategy should be applicable to other viruses, as long as at least part of their replication cycle can be supported in Drosophila cells.

Date: 2008
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DOI: 10.1038/nature07151

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