Transient FTY720 treatment promotes immune-mediated clearance of a chronic viral infection

Mary Premenko-Lanier (), Nelson B. Moseley, Sarah T. Pruett, Pablo A. Romagnoli and John D. Altman ()
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Mary Premenko-Lanier: Emory Vaccine Center and Department of Microbiology and Immunology
Nelson B. Moseley: Emory Vaccine Center and Department of Microbiology and Immunology
Sarah T. Pruett: Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, Georgia 30329, USA
Pablo A. Romagnoli: Emory Vaccine Center and Department of Microbiology and Immunology
John D. Altman: Emory Vaccine Center and Department of Microbiology and Immunology

Nature, 2008, vol. 454, issue 7206, 894-898

Abstract: FTY720: a dual-role drug? FTY720 (fingolimod) is a drug that has been tested in human clinical trials for treating multiple sclerosis and preventing kidney transplant rejection. It is regarded as a novel class of immunosuppressive agent that works by sequestering lymphocytes in lymph nodes, keeping them away from sites of pathology. Premenko-Lanier et al. now report a new and counter-intuitive use of FTY720: a three-day, low-dose course of FTY720 can both prevent establishment of a chronic lymphocytic choriomeningitis infection in mice, and cure an established chronic infection. Clearance of the virus is associated with an augmented immune response. The next question is, is this approach translatable to human chronic infections?

Date: 2008
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DOI: 10.1038/nature07199

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