New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

Yu-Hua Tseng (), Efi Kokkotou, Tim J. Schulz, Tian Lian Huang, Jonathon N. Winnay, Cullen M. Taniguchi, Thien T. Tran, Ryo Suzuki, Daniel O. Espinoza, Yuji Yamamoto, Molly J. Ahrens, Andrew T. Dudley, Andrew W. Norris, Rohit N. Kulkarni and C. Ronald Kahn
Additional contact information
Yu-Hua Tseng: Section on Obesity and Hormone Action, and,
Efi Kokkotou: Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, 02215, USA
Tim J. Schulz: Section on Obesity and Hormone Action, and,
Tian Lian Huang: Section on Obesity and Hormone Action, and,
Jonathon N. Winnay: Section on Obesity and Hormone Action, and,
Cullen M. Taniguchi: Section on Obesity and Hormone Action, and,
Thien T. Tran: Section on Obesity and Hormone Action, and,
Ryo Suzuki: Section on Obesity and Hormone Action, and,
Daniel O. Espinoza: Section on Obesity and Hormone Action, and,
Yuji Yamamoto: Section on Obesity and Hormone Action, and,
Molly J. Ahrens: Northwestern University, Evanston, Illinois 60208, USA
Andrew T. Dudley: Northwestern University, Evanston, Illinois 60208, USA
Andrew W. Norris: University of Iowa Children’s Hospital, Iowa City, Iowa 52242, USA
Rohit N. Kulkarni: Section on Cell and Molecular Physiology, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, 02215, USA
C. Ronald Kahn: Section on Obesity and Hormone Action, and,

Nature, 2008, vol. 454, issue 7207, 1000-1004

Abstract: BMP-7 and obesity Originally identified as a bone inducer, BMP-7 also has potent renal- and neuro-regenerative effects. Now it is reported to regulate energy homeostasis by promoting differentiation of brown, but not white, fat cells. BMP-7 switches on regulators of brown fat, including PRDM16 (see the cover story) and adipogenic transcription factors, and stimulates mitochondrial biogenesis. Ectopic expression of BMP-7 in mice increases brown, but not white, fat mass and leads to an increase in energy expenditure and reduced weight gain. These results have obvious therapeutic implications for the treatment of obesity.

Date: 2008
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DOI: 10.1038/nature07221

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