Mouse development with a single E2F activator

Shih-Yin Tsai, Rene Opavsky, Nidhi Sharma, Lizhao Wu, Shan Naidu, Eric Nolan, Enrique Feria-Arias, Cynthia Timmers, Jana Opavska, Alain de Bruin, Jean-Leon Chong, Prashant Trikha, Soledad A. Fernandez, Paul Stromberg, Thomas J. Rosol and Gustavo Leone ()
Additional contact information
Shih-Yin Tsai: College of Biological Sciences
Rene Opavsky: College of Biological Sciences
Nidhi Sharma: College of Biological Sciences
Lizhao Wu: College of Biological Sciences
Shan Naidu: Human Cancer Genetics Program, Comprehensive Cancer Center,
Eric Nolan: College of Biological Sciences
Enrique Feria-Arias: College of Biological Sciences
Cynthia Timmers: College of Biological Sciences
Jana Opavska: College of Biological Sciences
Alain de Bruin: College of Biological Sciences
Jean-Leon Chong: College of Biological Sciences
Prashant Trikha: College of Biological Sciences
Soledad A. Fernandez: Center for Biostatistics, The Ohio State University, Columbus, Ohio 43210, USA
Paul Stromberg: College of Veterinary Medicine, and
Thomas J. Rosol: College of Veterinary Medicine, and
Gustavo Leone: College of Biological Sciences

Nature, 2008, vol. 454, issue 7208, 1137-1141

Abstract: E2F proteins: reasons for diversity The E2F family is a family of proteins, some of which act as transcription activators and others as repressors. Here Shih-Yin Tsai et al. tested why there is such genetic complexity by inactivating the entire subset of activators singly or in combination in mice. They show that E2f3a is sufficient to support mouse embryonic and postnatal development. However, expression of E2f3b or E2f1 from the E2f3a locus suppressed all the postnatal phenotypes associated with the inactivation of E2f3a. They conclude there is functional redundancy among activators and that the requirement for E2f3a during postnatal development is dictated by its regulatory sequences, not by its protein function. These findings provide a molecular basis for the observed specificity among E2F activators during development.

Date: 2008
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DOI: 10.1038/nature07066

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