Crystal structure of the polymerase PAC–PB1N complex from an avian influenza H5N1 virus

Xiaojing He, Jie Zhou, Mark Bartlam, Rongguang Zhang, Jianyuan Ma, Zhiyong Lou, Xuemei Li, Jingjing Li, Andrzej Joachimiak, Zonghao Zeng, Ruowen Ge, Zihe Rao () and Yingfang Liu ()
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Xiaojing He: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Jie Zhou: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Mark Bartlam: College of Life Sciences and Tianjin State Laboratory of Protein Sciences, Nankai University
Rongguang Zhang: Midwest Center for Structural Genomics and Structural Biology Center, Argonne National Laboratory, Argonne, Illinois 60439, USA
Jianyuan Ma: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Zhiyong Lou: Laboratory of Structural Biology, Tsinghua University
Xuemei Li: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Jingjing Li: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Andrzej Joachimiak: Midwest Center for Structural Genomics and Structural Biology Center, Argonne National Laboratory, Argonne, Illinois 60439, USA
Zonghao Zeng: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Ruowen Ge: National University of Singapore
Zihe Rao: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Yingfang Liu: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences

Nature, 2008, vol. 454, issue 7208, 1123-1126

Abstract: Influenza virus: polymerase structures determined Influenza A virus polymerase consists of three proteins, PA, PB1 and PB2, and is critical for transcription and replication. Two groups now report the crystal structure of the avian H5N1 PA C-terminal domain in complex with the PA binding domain of PB1. The structure work may be useful for the design of novel antiviral drugs.

Date: 2008
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DOI: 10.1038/nature07120

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