Multipotent somatic stem cells contribute to the stem cell niche in the Drosophila testis

Justin Voog, Cecilia D’Alterio and D. Leanne Jones ()
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Justin Voog: Laboratory of Genetics, The Salk Institute for Biological Studies, and,
Cecilia D’Alterio: Laboratory of Genetics, The Salk Institute for Biological Studies, and,
D. Leanne Jones: Laboratory of Genetics, The Salk Institute for Biological Studies, and,

Nature, 2008, vol. 454, issue 7208, 1132-1136

Abstract: Stem cell niches are for life Adult stem cells occupy specialized microenvironments, or niches, that help regulate stem cell renewal and maintenance. The stem cell niche in the Drosophila male gonad is located at the tip of the testis where germline and somatic stem cells surround the apical hub. Voog et al. now show that somatic stem cells in the Drosophila testis contribute to both the apical hub and the somatic cyst cell lineage comprising the niche. They also show that the transcriptional repressor escargot regulates the ability of somatic cells to assume and/or maintain hub cell identity. This work highlights the dynamic relationship between stem cells and the niche and provides insight into genetic programmes that regulate niche size and function to support normal tissue homeostasis and organ regeneration throughout life.

Date: 2008
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DOI: 10.1038/nature07173

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