Metabolic gene regulation in a dynamically changing environment

Matthew R. Bennett, Wyming Lee Pang, Natalie A. Ostroff, Bridget L. Baumgartner, Sujata Nayak, Lev S. Tsimring and Jeff Hasty ()
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Matthew R. Bennett: and
Wyming Lee Pang: and
Natalie A. Ostroff: and
Bridget L. Baumgartner: and
Sujata Nayak: and
Lev S. Tsimring: Institute for Nonlinear Science, University of California, San Diego, La Jolla, California 92093, USA
Jeff Hasty: and

Nature, 2008, vol. 454, issue 7208, 1119-1122

Abstract: Gene regulation: coping with change Living organisms have evolved under pressure to constantly adapt to rapidly changing environmental conditions. Yet cellular functions are usually studied under stable laboratory conditions or abrupt changes at best. Bennett et al. have now developed a microfluidics platform to present yeast cells with smoothly periodic changes in culture conditions. They observe that the yeast metabolic system reliably responds to slowly changing environment but filters out fast fluctuations. They then show that mutant cells that differed when probed in static environments have actually been optimized for similarly robust responses to dynamically changing environments. Finally, coupling this new approach with mathematical modelling, they predict and experimentally confirm a new regulatory link between the glucose and galactose signalling pathways.

Date: 2008
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DOI: 10.1038/nature07211

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