Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

Libor Macůrek, Arne Lindqvist, Dan Lim, Michael A. Lampson, Rob Klompmaker, Raimundo Freire, Christophe Clouin, Stephen S. Taylor, Michael B. Yaffe and René H. Medema ()
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Libor Macůrek: University Medical Center Utrecht
Arne Lindqvist: University Medical Center Utrecht
Dan Lim: Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Michael A. Lampson: University of Pennsylvania, Philadelphia, Pennsylvania 19104-6069, USA
Rob Klompmaker: University Medical Center Utrecht
Raimundo Freire: Unidad de Investigación, Hospital Universitario de Canarias
Christophe Clouin: Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Stephen S. Taylor: Faculty of Life Sciences, University of Manchester
Michael B. Yaffe: Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
René H. Medema: University Medical Center Utrecht

Nature, 2008, vol. 455, issue 7209, 119-123

Abstract: Cell division: PLK1 and aurora A at the checkpoint Polo-like kinase-1 (PLK1) is an essential mitotic kinase regulating multiple aspects of the cell division process. Here, activation of PLK1 is shown to occur before mitosis and to depend on phosphorylation by aurora-A kinase, facilitated by a cofactor Bora. The initial activation of PLK1 seems to be a primary function of aurora-A.

Date: 2008
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DOI: 10.1038/nature07185

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