Neurogenin 2 controls cortical neuron migration through regulation of Rnd2

Julian Ik-Tsen Heng, Laurent Nguyen, Diogo S. Castro, Céline Zimmer, Hendrik Wildner, Olivier Armant, Dorota Skowronska-Krawczyk, Francesco Bedogni, Jean-Marc Matter, Robert Hevner and François Guillemot ()
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Julian Ik-Tsen Heng: National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
Laurent Nguyen: National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
Diogo S. Castro: National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
Céline Zimmer: National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
Hendrik Wildner: National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
Olivier Armant: National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
Dorota Skowronska-Krawczyk: Sciences II, University of Geneva
Francesco Bedogni: University of Washington School of Medicine, Harborview Medical Center, Seattle, Washington 98104, USA
Jean-Marc Matter: Sciences II, University of Geneva
Robert Hevner: University of Washington School of Medicine, Harborview Medical Center, Seattle, Washington 98104, USA
François Guillemot: National Institute for Medical Research, Mill Hill, London NW7 1AA, UK

Nature, 2008, vol. 455, issue 7209, 114-118

Abstract: Neuronal migration: neurogenin 2 acts via Rnd2 Proneural transcription factors, such as neurogenin 2, are thought to control the expression of many genes during brain development to promote both the differentiation of neurons and their migration to their final locations in the cerebral cortex. A new study reveals that overexpression of a single target of neurogenin 2, Rnd2, can restore the neuronal migration defects of Neuogenin2-depleted neurons. Rnd2 is thus an atypical member of the Rho family of small GTP-ases, which regulate actin cytoskeleton dynamics, with its activity regulated at the gene transcription level, rather than by the usual post-translational GTP/GDP cycle.

Date: 2008
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DOI: 10.1038/nature07198

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