RNA interference screen for human genes associated with West Nile virus infection

Manoj N. Krishnan, Aylwin Ng, Bindu Sukumaran, Felicia D. Gilfoy, Pradeep D. Uchil, Hameeda Sultana, Abraham L. Brass, Rachel Adametz, Melody Tsui, Feng Qian, Ruth R. Montgomery, Sima Lev, Peter W. Mason, Raymond A. Koski, Stephen J. Elledge, Ramnik J. Xavier, Herve Agaisse and Erol Fikrig ()
Additional contact information
Manoj N. Krishnan: Section of Infectious Diseases,
Aylwin Ng: Center for Computational and Integrative Biology, and Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Bindu Sukumaran: Section of Infectious Diseases,
Felicia D. Gilfoy: University of Texas Medical Branch, Galveston, Texas 77555, USA
Pradeep D. Uchil: Section for Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticutt 06520-8031, USA
Hameeda Sultana: Section of Infectious Diseases,
Abraham L. Brass: Center for Genetics and Genomics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Rachel Adametz: Section for Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticutt 06520-8031, USA
Melody Tsui: Department of Systems Biology,
Feng Qian: Section of Rheumatology
Ruth R. Montgomery: Section of Rheumatology
Sima Lev: Weizmann Institute of Science
Peter W. Mason: University of Texas Medical Branch, Galveston, Texas 77555, USA
Raymond A. Koski: L2 Diagnostics, 300 George Street, New Haven, Connecticutt 06511, USA
Stephen J. Elledge: Center for Genetics and Genomics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Ramnik J. Xavier: Center for Computational and Integrative Biology, and Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Herve Agaisse: Section for Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticutt 06520-8031, USA
Erol Fikrig: Section of Infectious Diseases,

Nature, 2008, vol. 455, issue 7210, 242-245

Abstract: West Nile virus: interaction with human cells This manuscript reports a comprehensive systems level description of the molecular signatures governing the interaction of West Nile virus with human cells. A whole-genome human RNA interference gene silencing screen in HeLa cells identified 305 host proteins genes that facilitate West Nile virus infection of human cells. A number of the identified also play a role in the infection of dengue virus, another flavivirus related to West Nile virus. This work highlights differences in the molecular pathogenesis of related flaviviruses, and points to several possible new targets for antiviral drugs

Date: 2008
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DOI: 10.1038/nature07207

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