Heterochromatin links to centromeric protection by recruiting shugoshin

Yuya Yamagishi, Takeshi Sakuno, Mari Shimura and Yoshinori Watanabe ()
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Yuya Yamagishi: Laboratory of Chromosome Dynamics, Institute of Molecular and Cellular Biosciences,
Takeshi Sakuno: Laboratory of Chromosome Dynamics, Institute of Molecular and Cellular Biosciences,
Mari Shimura: International Medical Center of Japan
Yoshinori Watanabe: Laboratory of Chromosome Dynamics, Institute of Molecular and Cellular Biosciences,

Nature, 2008, vol. 455, issue 7210, 251-255

Abstract: Centromere function: mitosis versus meiosis The centromere of a chromosome contains regions of heterochromatin that have diverse roles during chromosome segregation. Here, the authors demonstrate in fission yeast that during mitosis, the main function for centromeric heterochromatin is to recruit cohesin. In contrast, during meiosis, the most important function for heterochromatin is to recruit the cohesin protector shugoshin to centromeres. This function is conserved in human cells.

Date: 2008
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DOI: 10.1038/nature07217

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