Structure of the 30S translation initiation complex

Angelita Simonetti, Stefano Marzi, Alexander G. Myasnikov, Attilio Fabbretti, Marat Yusupov, Claudio O. Gualerzi and Bruno P. Klaholz ()
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Angelita Simonetti: Institute of Genetics and of Molecular and Cellular Biology
Stefano Marzi: Institute of Genetics and of Molecular and Cellular Biology
Alexander G. Myasnikov: Institute of Genetics and of Molecular and Cellular Biology
Attilio Fabbretti: Laboratory of Genetics, University of Camerino
Marat Yusupov: Institute of Genetics and of Molecular and Cellular Biology
Claudio O. Gualerzi: Laboratory of Genetics, University of Camerino
Bruno P. Klaholz: Institute of Genetics and of Molecular and Cellular Biology

Nature, 2008, vol. 455, issue 7211, 416-420

Abstract: Protein synthesis: the 30S complex Proteins known as initiation factors (IFs) help to position the 30S subunit of the ribosome correctly on the mRNA start site so that the proper reading frame is engaged. After formation of this 30S initiation complex, the 50S ribosomal subunit binds and the IFs are released. In this work, Simonetti et al. use cryo-electron microscopy to examine the position of the mRNA, initiator tRNA, IF1 and IF2 in the 30S particle. From this structure, they predict how the 50S subunit interacts with the 30S initiation complex, and how GTP bound to IF2 is positioned towards the incoming GTPase-activated centre of the 50S.

Date: 2008
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DOI: 10.1038/nature07192

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