Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance

Jelena Nedjic, Martin Aichinger, Jan Emmerich, Noboru Mizushima and Ludger Klein ()
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Jelena Nedjic: Research Institute of Molecular Pathology, Doktor Bohr Gasse 7, 1030 Vienna, Austria
Martin Aichinger: Research Institute of Molecular Pathology, Doktor Bohr Gasse 7, 1030 Vienna, Austria
Jan Emmerich: Research Institute of Molecular Pathology, Doktor Bohr Gasse 7, 1030 Vienna, Austria
Noboru Mizushima: Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8613, Japan
Ludger Klein: Research Institute of Molecular Pathology, Doktor Bohr Gasse 7, 1030 Vienna, Austria

Nature, 2008, vol. 455, issue 7211, 396-400

Abstract: T-cell tolerance Macro-autophagy in thymic epithelial cells is shown to contribute to endogenous antigen processing and selection of major histocompatibility complex class II (MHC II)-restricted CD4 T cells. This suggests that autophagy focuses the MHC class II/peptide repertoire of these T cells on their intracellular milieu, which is made up of a wide array of otherwise strictly 'tissue-specific' self-antigens. In doing so, it contributes to efficient positive selection and is essential for the generation of a self-tolerant T-cell repertoire.

Date: 2008
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DOI: 10.1038/nature07208

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