Platelet-derived growth factor-α receptor activation is required for human cytomegalovirus infection

Liliana Soroceanu, Armin Akhavan and Charles S. Cobbs ()
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Liliana Soroceanu: California Pacific Medical Center Research Institute, Suite 220, 475 Brannan Street, San Francisco, California 94107, USA
Armin Akhavan: California Pacific Medical Center Research Institute, Suite 220, 475 Brannan Street, San Francisco, California 94107, USA
Charles S. Cobbs: California Pacific Medical Center Research Institute, Suite 220, 475 Brannan Street, San Francisco, California 94107, USA

Nature, 2008, vol. 455, issue 7211, 391-395

Abstract: Human cytomegalovirus: dependence on PDGFR-α Human platelet derived growth factor-alpha (PDGFR-α) receptor has been found to be a requirement for the infection of human cells by human cytomegalovirus (HCMV), the herpesvirus that's the most common cause of congenital human infections, and causes life threatening disease in HIV-infected and transplant patients. If the receptor is inactivated, HCMV cannot enter the cell and viral genes are not expressed. Importantly, two currently available pharmaceutical agents — the anticancer drug imatinib (Gleevec) and PDGFR-α blocking antibody IMC-3G3 — are active against the virus in human cells suggesting that they might prove useful in the treatment of HCMV infection.

Date: 2008
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DOI: 10.1038/nature07209

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