Natural products as inspiration for the development of asymmetric catalysis

Justin T. Mohr, Michael R. Krout and Brian M. Stoltz
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Justin T. Mohr: The Arnold and Mabel Beckman Laboratories of Chemical Synthesis, California Institute of Technology, 1200 East California Boulevard, MC 164-30
Michael R. Krout: The Arnold and Mabel Beckman Laboratories of Chemical Synthesis, California Institute of Technology, 1200 East California Boulevard, MC 164-30
Brian M. Stoltz: The Arnold and Mabel Beckman Laboratories of Chemical Synthesis, California Institute of Technology, 1200 East California Boulevard, MC 164-30

Nature, 2008, vol. 455, issue 7211, 323-332

Abstract: Abstract Biologically active natural products often contain particularly challenging structural features and functionalities in terms of synthesis. Perhaps the greatest difficulties are those caused by issues of stereochemistry. A useful strategy for synthesizing such molecules is to devise methods of bond formation that provide opportunities for using enantioselective catalysis. In using this tactic, the desire for a particular target structure ultimately drives the development of catalytic methods. New enantioselective catalytic methods contribute to a greater fundamental understanding of how bonds can be constructed and lead to valuable synthetic technologies that are useful for a variety of applications.

Date: 2008
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DOI: 10.1038/nature07370

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